Guinea Pig Whole Blood
Cayman Chemical DocosahexaenoIc ACD ethyl50mg
A TEAD1 inhibitor (IC50 1.02 nM) inhibits TEAD autopalmitoylation in HEK293 cells expressing TEAD1 but not HEK293 cells expressing TEAD2 TEAD3 or TEAD4 at 3 UM inhibits palmitoylation of endogenous TEAD1 in NCI-H2373 cells reduces tumor volume in NCI-H2373 and NCI H226 mesothelioma mouse xenograft models
Cayman Chemical EIcosapentaenoIc ACD ethyl1mg
An ALDH1A3 inhibitor (IC50 5.14 nM) potentiates glucose-induced insulin secretion from pancreatic islets isolated from patients with type 2 diabetes at 10 UM decreases plasma insulin levels and reduces blood glucose levels in an IPGTT in diabetic db/db male mice at 40 mg/kg per day decreases blood glucose levels and increases plasma insulin levels in a mouse model of high-fat diet-induced obesity at 270 ppm in the diet
Cayman Chemical ArachIdonIc ACD sulfonatS
An M4 muscarinic receptor PAM selective for M4 mAChRs over a panel of 59 receptors ion channels transporters and enzymes at 10 UM selectively potentiates ACh-induced activation of the M4 mAChR over M1-M3 and M5 mAChRs in cells expressing the human receptors (EC50s 12.3 4798 >10000 >10000 and >10000 nM respectively) inhibits amphetamine-induced locomotor activity in mice and prepulse inhibition deficits in rats at 3.2 mg/kg
Cayman Chemical GlycoursodeoxycholIc ACD 250mg
A P-gp inhibitor inhibits the efflux of [3H]vinblastine by ABCB1 in Caco-2 colon cancer cells (EC50 0 05 UM) inhibits the efflux of rhodamine-123 and calcein-AM by BCRP and MRP1 in MDCK cells (EC50s 73 and 9 3 UM respectively) enhances growth inhibition of MCF-7/ADR breast cancer cells at 2 or 20 UM when used in combination with doxorubicin in vitro but does not alter the effectiveness of doxorubicin on growth inhibition in Caco-2 cells increases phosphorylation of p38 and JNK in Caco-2 cells and MCF-7/ADR cells when used at a concentration of 20 UM
Cayman Chemical EIcosapentaenoIc ACD ethyl50ug
A FAAH inhibitor (IC50s 0.028 and 0.1 UM for the human and rat enzymes respectively)
Cayman Chemical DocosahexaenoIc ACD ethyl S
An activator of KATP channels induces relaxation of potassium-precontracted isolated guinea pig bladder detrusor muscle strips (EC50 0.5 UM) reduces bladder overactivity in a rat model of ligature-intact partial urethral obstruction
Cayman Chemical DocosahexaenoIc ACD ethyl S
An activator of KATP channels induces relaxation of potassium-precontracted isolated guinea pig bladder detrusor muscle strips (EC50 0.5 UM) reduces bladder overactivity in a rat model of ligature-intact partial urethral obstruction
Cayman Chemical DocosahexaenoIc ACD ethyl50UG
A urotensin II receptor antagonist (Kis 61 17 30 65 and 56 nM for the human monkey cat rat and mouse receptors respectively) reduces urotensin II-induced increases in the expression of IL1B IL6 and VCAM1 in EA.hy926 cells at 1 UM reduces urotensin II-induced adhesion of U937 monocytes to EA.hy926 cells at 1 UM
Cayman Chemical aLInolenIc ACD methyl STR
A polyphenol with diverse biological activities inhibits PDE4D2 and PDE4B2 (IC50s 1.9 and 4.5 UM respectively) induces cell death in P388 cells (IC50 24.8 UM) inhibits IL-1B-induced increases in the levels of phosphorylated ERK and JNK in A549 cells at 30 or 50 UM inhibits LPS-induced increases in NO and iNOS levels in MH-S macrophages at 50 and 60 UM respectively inhibits LPS-induced increases in the number of neutrophils alveolar macrophages and dendritic cells in BALF the thickness of alveolar walls and the levels of NF-KB in the lungs in a rat model of acute lung injury at 60 mg/kg
Cayman Chemical Linolenic ACD 250mg
A triterpenoid with diverse biological activities inhibits the proliferation of Meth A and LLC1 cancer cells (IC50s 3.4 and 12.5 UG/ml respectively) reduces the viability of RAW 264.7 macrophages at 20 UM inhibits fMLF- and cytochalasin B-induced superoxide generation in and elastase release from isolated human neutrophils (IC50s 6.36 and 5.01 UG/ml) inhibits complement-dependent hemolysis of isolated sheep red blood cells (IC50 41.7 UM)
Cayman Chemical Galc Acd 50g
A selectve antagonst of DP1 (K 1 6 nM) blocks PGD2nduced plasma exudaton n the conjunctva (ED50 0 099 mg/kg) and suppresses antgennduced allergc responses n gunea pgs
Cayman Chemical Galc Acd 10g
Cayman s Thromboxane B2 (TXB2) Express ELSA Kt Monoclonal s a compettve assay that can be used for quantfcaton of TXB2 n serum urne tssue culture supernatants and other sample matrces The assay has a range from 15 62000 pg/ml and a senstvty (80 B/B0) of approxmately 45 pg/ml
LAMPIRE Biological Laboratories GUINEA PIG BLOOD K2 EDTA 50ML
Guinea Pig, Whole Blood, K2 Edta, Donor, Gender Unspecified, 50 Ml
Cayman Chemical LNgchaIn Faty ACD Methyl 100mg
A diacylglycerol has been found in olive oil subjected to lipase-catalyzed glycerolysis with immobilized lipase B from C antarctica